Beyond longevity: healthy longevity

Immunological Approaches for Healthy Longevity

As the body ages, the function of various organs changes, bringing sensory expression of “decline” into use, but the background of this phenomenon suggests a role for factors such as cumulative oxidative stress, hypoxia associated with circulatory failure, and lipid peroxidation. Age-related changes and aging are not related directly to passage of time, and the extent of changes differs dependi...

Bile acids extend longevity beyond calorie restriction

discovery of potential anti-aging treatment capable of extending both our healthy aging and perhaps our longevity resuscitated an old human dream. It also brought about inordinate interest in these studies. While calorie restriction (CR) is still the best known intervention to increase life span, anti-aging molecules could mimic this effect without reducing nutrient intake. Such compounds, like...

Calorie Restriction, Longevity and Cognitive Function

Beyond the Grandmother Hypothesis: Evolutionary Models of Human Longevity

Scientific Longevity

We have made use of gene expression analysis of peripheral blood (PB) mononuclear cells to develop expression profiles that accurately reflect prior radiation exposure. We demonstrate that expression profiles can be developed that not only predict radiation exposure in mice but also distinguish the level of radiation exposure, ranging from 50 cGy to 1,000 cGy. Likewise, a molecular signature of...